SUNG-UNG KANG Dr.Med.Sc

Assistant Professor
Institute for Cell Engineering (Neuroregeneration program)
Department of Neurology;
The Johns Hopkins School of Medicine, Baltimore
(MRB Rm753; e-mail: skang34(at)jhmi.edu)

About Kang's Lab

Kang's Lab aims to identify the key molecular hubs causing selective vulnerability in Parkinson's disease (PD) and Alzheimer's Disease (AD), which are crucial to identify discriminative markers for diagnosis and new treatment modalities. A hypothesis "Gut-Brain Axis" associated with DNA damages and Sleep disorders, known as a bidirectional complexity triggering the progressive neurodegenerations, has been tested using experimental data obtained from genetically associated transgenic mice as well as formidable data generated from human post-mortem tissues. To further provide a comprehensive perspective, we have been developing unique bioinformatic algorithms and building data structure for deep learning-based genomic data integration. State-of-the-art technologies incl. in-house developed single-cell genomics (HiF-snRNAseq; High Efficient single nuclei RNA sequencing), spatial genomics (10x Genomics), metagenomics (Illumina), and epigenomics including Cut&Tag, WGBS, ATAC-seq, Hi-C have been applied for data collection. 

Keywords

#Neurodegenerative diseases, #Parkinson's disease (PD), #Alzheimer's disease (AD), #Gut-Brain axis, #Single-cell genomics, #Epigenomics, #Big Data, #Deep learning, #Molecular Circadian rhythms, #Transgenic animals, #Identification of cell-type specific diagnostic markers

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Post-mortem brains
COVID19 brains
ACD multiplex
Single-cell genomics
Gut injection
 miRNA
Stroke
Drosophila TRAP Control
Sung Ung Kang Picture.png

Lab space
& state of the art research equipments

Lab Rm720
Lab Rm720

Experimental Bench

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Lab Rm732
Lab Rm732

Experimental Bench

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Bioinformatic Rm743
Bioinformatic Rm743

Computing space / Server

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Kang Lab Facility Room
Kang Lab Facility Room

Lab major equipments

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Illumina Sequencers
Illumina Sequencers

NextSeq550 / MiniSeq

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ZEISS Lightsheet Z.1
ZEISS Lightsheet Z.1

Multiview Imaging of Living and Cleared Specimens

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LCM PALM CombiSystem (ZEISS)
LCM PALM CombiSystem (ZEISS)
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FACS (Sony MA600)
FACS (Sony MA600)

Lab own FACS for single-cell sorting

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Quanterix SR-Plex
Quanterix SR-Plex

Development of High-trhoughput diagnostic test

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epMotion 5075tc NGS
epMotion 5075tc NGS
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FPLC (GE:AKTA system)
FPLC (GE:AKTA system)

AKTA pure 25L with Fraction collector F9-R

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TapeStation4150 (Agilent)
TapeStation4150 (Agilent)

RNA/DNA QC for sequencing

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Veriti 96-well Thermo Cycler (Thermo)
Veriti 96-well Thermo Cycler (Thermo)

10 Thermo cyclers in lab for HT library generation

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OMNI Prep multi-sample Process
OMNI Prep multi-sample Process

Sample Prep/Nuclei Preparation (max 6 samples)

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PippinHT and Qubit
PippinHT and Qubit

Sequencing Library purification and QC

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HybEZ-II Oven (ACD; ISH)
HybEZ-II Oven (ACD; ISH)

ACD In-situ Hybidization

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Confocal microscopes (ICE)
Confocal microscopes (ICE)
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Computing-MARCC
Computing-MARCC

Maryland Advanced Research Computing Center (MARCC): Total cores: 23,280, 1.4PFLOPs

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MRB Research Animal Facility
MRB Research Animal Facility

Research animal facility in same building. Animal procurement, housing, clinical care and veterinary research support and collaboration.

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#Lab, #ICE, #JHMI  Media Appearances

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Inclusion is in our DNA | Johns Hopkins Founding Letter

Inclusion is in our DNA | Johns Hopkins Founding Letter

02:32
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Welcome to the Johns Hopkins Institute for Cell Engineering (ICE)

Welcome to the Johns Hopkins Institute for Cell Engineering (ICE)

01:46
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125 Years of the Johns Hopkins School of Medicine

125 Years of the Johns Hopkins School of Medicine

08:44
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Johns Hopkins Medicine 2019 Nobel Prize Celebrations | Gregg Semenza

Johns Hopkins Medicine 2019 Nobel Prize Celebrations | Gregg Semenza

03:42
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The Neuroregeneration Program at Johns Hopkins’ Institute for Cell Engineering

The Neuroregeneration Program at Johns Hopkins’ Institute for Cell Engineering

02:34
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MARCC Construction

MARCC Construction

04:14
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U.S. News and World Report's Best Hospital 2020-21 Update from Dr. Justin McArthur

U.S. News and World Report's Best Hospital 2020-21 Update from Dr. Justin McArthur

02:08
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The Institute for Cell Engineering (ICE) at Johns Hopkins

The Institute for Cell Engineering (ICE) at Johns Hopkins

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© 2021 Created by Dr.SUNG UNG KANG 

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